I went in 3 day weekend Trip with my friend to Prague last year. I was really exited because I hear so much about how Cool the city was, nice place to go hard partying and also was pretty cheaper than other EU-Cities. So I embraced this Idea, booked an Airbnb room that seem quite nice Quartier. Later to find out it was indeed near the Center but access were quite demanding of physical conditions (up and down hill every day). Old Town (Stare Mesto) - Its the most popular area. There are many shops, restaurantes and its near Charles bridge that is really a must-see in the city. I would totally recommend to go afternoon and stay nearby to see the sunset. Prague Castle - It's huge and you need a lot of time to walk all around. I would recommend to start a day going to the Castle and later of the day finishing at Old Town to see the sunset, have a beer nearby or Dinner. Some people hired segways to move faster and dont get tired. John Lehnno...